Canada and Holland allow the medical use of cannabis
Smoking large amounts of cannabis for therapeutic reasons may increase rather than reduce pain, a US study suggests.
The pain-relieving qualities of cannabis have long been hailed, and several countries have made it available for medicinal purposes.
But quantity is key, according to the study in the journal Anesthesiology.
University of California researchers found moderate use had the greatest impact on pain in 15 volunteers, while large doses actually made pain worse.
The team recruited 15 healthy volunteers, in whom pain was induced by injecting capsaicin - the "hot" chemical found in chilli peppers - under their skin.
They were then given cannabis to smoke. The strength of the dose was determined by the tetrahydrocannabinol content, which is the main active chemical in cannabis.
Some of the volunteers were given a placebo.
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